Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies
Identifieur interne : 000411 ( Main/Exploration ); précédent : 000410; suivant : 000412Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies
Auteurs : G. Giovannoni ; J. O'Sullivan ; K. Turner ; A. Manson ; A. LeesSource :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 2000.
Abstract
Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction. The disorder has been recognised as a consequence of dopamine replacement therapy (DRT) in 15 patients with Parkinson's disease. The syndrome typically develops in male patients with early onset Parkinson's disease, and can occur with orally and subcutaneously administered DRT. These patients take increasing quantities of their DRT, despite increasingly severe drug induced dyskinesias, and may develop a cyclical mood disorder with hypomania or manic psychosis. There is impairment of social and occupational functioning. Tolerance develops to mood elevating effects of DRT and a negative affective withdrawal state occurs if the drugs are withdrawn or doses decreased. The clinical features and guidelines for managing this syndrome are discussed. A set of diagnostic criteria for further investigating this condition is proposed.
Url:
DOI: 10.1136/jnnp.68.4.423
PubMed: 10727476
PubMed Central: 1736875
Affiliations:
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Parkinson's disease on dopamine replacement therapies</title><author><name sortKey="Giovannoni, G" sort="Giovannoni, G" uniqKey="Giovannoni G" first="G" last="Giovannoni">G. Giovannoni</name></author><author><name sortKey="O Sullivan, J" sort="O Sullivan, J" uniqKey="O Sullivan J" first="J" last="O'Sullivan">J. O'Sullivan</name></author><author><name sortKey="Turner, K" sort="Turner, K" uniqKey="Turner K" first="K" last="Turner">K. Turner</name></author><author><name sortKey="Manson, A" sort="Manson, A" uniqKey="Manson A" first="A" last="Manson">A. Manson</name></author><author><name sortKey="Lees, A" sort="Lees, A" uniqKey="Lees A" first="A" last="Lees">A. Lees</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hedonistic homeostatic dysregulation is a
neuropsychological behavioural disorder associated with substance
misuse and addiction. The disorder has been recognised as a consequence
of dopamine replacement therapy (DRT) in 15 patients with Parkinson's
disease. The syndrome typically develops in male patients with early
onset Parkinson's disease, and can occur with orally and
subcutaneously administered DRT. These patients take increasing
quantities of their DRT, despite increasingly severe drug induced
dyskinesias, and may develop a cyclical mood disorder with hypomania or
manic psychosis. There is impairment of social and occupational
functioning. Tolerance develops to mood elevating effects of DRT and a
negative affective withdrawal state occurs if the drugs are withdrawn
or doses decreased. The clinical features and guidelines for managing this syndrome are discussed. A set of diagnostic criteria for further
investigating this condition is proposed.
</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Giovannoni, G" sort="Giovannoni, G" uniqKey="Giovannoni G" first="G" last="Giovannoni">G. Giovannoni</name><name sortKey="Lees, A" sort="Lees, A" uniqKey="Lees A" first="A" last="Lees">A. Lees</name><name sortKey="Manson, A" sort="Manson, A" uniqKey="Manson A" first="A" last="Manson">A. Manson</name><name sortKey="O Sullivan, J" sort="O Sullivan, J" uniqKey="O Sullivan J" first="J" last="O'Sullivan">J. O'Sullivan</name><name sortKey="Turner, K" sort="Turner, K" uniqKey="Turner K" first="K" last="Turner">K. Turner</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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